Mewtwo is one of the most famous Pokemon in the Pokemon TCG and it appears in certain sets as one of the most desirable chase cards whenever it’s featured. Although the best sets with Mewtwo chase cards also have incredibly valuable cards to collect, this list isn’t purely about the sets with the highest-valued cards.
Instead, these sets will combine value, variety, and affordability as three of the essential components that make a great Mewtwo set. Ideally, the best set of Mewtwo chase cards offers several possible Mewtwo pulls, some valuable cards, and a relatively low cost to open each product, relative to the top chase card’s cost.
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XY Evolutions – Three Mewtwo
Simple And Sizzling
XY Evolutions may not have the greatest number of Mewtwo chase cards in this set, but the three cards you can find offer slick artwork that gives you a different look at Mewtwo each time. From the Ultra Rare EX versions to the classic appearance of the Rare, you have a few options for your preferred style.
While the maximum value of these three Mewtwo cards only hits about $20, each card is visually stunning and is a worthy addition to any Mewtwo collection. Disappointingly, this set isn’t exactly cheap to open, so the value you’ll receive in return isn’t particularly exciting.
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Unified Minds – Three Mewtwo
Part Of The Team
Unified Minds is full of valuable cards featuring Tag Team duos that combine to form some of the most beloved pairings in the Pokemon TCG. One such pairing is Mew and Mewtwo, who boast three separate cards that feature the dynamic duo in battle poses.
The two more valuable Mew and Mewtwo combinations feature the same art of both Pokemon staring at the audience, but a third version that uses an in-battle scene is even more impressive, featuring powerful poses from Mew and Mewtwo as they clash with an unseen competitor.
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Shining Legends – Four Mewtwo
Testing The Waters
If you love the most valuable Shining Legends cards in the Pokemon TCG, then you’ll be overjoyed to see Mewtwo at the top of the list of this set’s chase cards. Shining Legends’ best cards offer solid value across the board and three of the four Mewtwo present solid prices that would warrant a cheer if you are lucky enough to pull them.

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However, the real celebration can start if you pull the Shiny Holo Rare Mewtwo GX, which sits around the $350 mark, giving you a massive return on your investment if you’re able to pull this card fairly early in your pack-opening journey. While each pack will run you north of $40, it’s worth it for the thrill of pulling this Mewtwo chase card.
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Pokemon GO – Five Mewtwo
An Iconic Scene
Who wouldn’t be excited about a chance to pull one of five Mewtwo cards? With only two cards sharing the same artwork, this collection of Mewtwo chase cards is impressive. Unfortunately, there’s no denying that pulling any of these cards won’t be a massive financial boon, as even the top card is worth less than $50.
However, if you’re just a Mewtwo aficionado who wants to collect as many unusual versions of Mewtwo as possible, then Pokemon GO is a great option for you. As one of the cheapest Pokemon TCG sets available, Pokemon GO offers superior value for Mewtwo fans, as the packs are some of the cheapest you can find, with five ways to come out with a great Mewtwo card.
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XY BREAKthrough – 11 Mewtwo
An Overwhelming Variety
XY BREAKthrough’s collection of valuable cards is extremely underrated, especially when it comes to Mewtwo, as this Legendary Pokemon boasts a massive assortment of beautiful cards to enjoy. There are 11 gorgeous Mewtwo chase cards in XY BREAKthrough, with six of the cards offering full art versions that will take your breath away.
Mega Mewtwo X and Y are the highlights of XY BREAKthrough, standing out with a handful of Mewtwo cards each.
In addition to the excellent variety, the top four Mewtwo cards from this set are valuable, as each one commands over $60. While most of the other Mewtwo cards in XY BREAKthrough hover around the $25 mark or below, they’re all visually distinct masterpieces that will excite you if you’re lucky enough to pull one of them.
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