![The Four-Stage Drug Used To Kill [SPOILER], Explained](https://esportvoice.com/wp-content/uploads/2025/03/The-Four-Stage-Drug-Used-To-Kill-SPOILER-Explained-1600x800.jpg)
Summary
- The Anti-Kibutsuji drug was pivotal in defeating Muzan by converting him into a human, rapidly aging him, and breaking him down at a cellular level.
- The drug weakened Muzan substantially, preventing his escape from battle and stopping his regenerative abilities.
- Without Tamayo’s sacrifice to inject the drug and Shinobu’s expertise, Muzan would have easily won the final battle.
During the final battle of Demon Slayer: Kimetsu No Yaiba, the Demon Slayer corps faces the most powerful demon of all time, Muzan Kibutsuji. Many lives had already been lost to this monster, as even the strongest Hashira were unable to counter his overwhelming power.
As Muzan kept on killing the members of the corps, he failed to realize that there was yet another powerful weapon that had been prepared specifically to defeat him. This weapon was none other than the Anti-Kibutsuji drug. Made by the collaborative efforts of Tamayo, Yushiro, and Shinobu, this drug proved to be extremely useful in defeating Muzan once and for all.
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The Four-Effect Drug Preparation For The Battle Against Muzan
How Did The Anti-Kibutsuji Drug Work?
Despite Shinobu’s deep hatred for demons, she put aside her grudges and worked together with Tamayo, knowing it was the only way to stop Muzan. Tamayo knew Muzan very well and was aware of his strengths and weaknesses.
We don’t have the strength to fight Muzan head-on, so we will take away his power instead – Tomayo
Her knowledge, combined with Shinobu’s expertise in Wisteria Poison used against demons, gave us the powerful Anti Kibutsuji drug which turned the odds of the battle in their favor. The drug itself was meant to have four major effects on Muzan.
Converting Muzan Into A Human
The first effect of the drug was to convert Muzan into a human. This was definitely pretty risky as the transformation into a demon is considered a permanent one and the only way out of this curse is death. However, Tamayo had spent ages finding a possible cure to reverse the curse and turn a demon into a human once again.
Tamayo had also been studying Nezuko’s blood after every battle she went through. However, the first effect failed and, if only it had worked, Muzan would have turned into a human and it would have been much easier to defeat him. The drug did weaken him considerably, but Tamayo and Shinobu knew that they would need much more than this to defeat Muzan. To ensure his downfall, they designed it with three additional effects.
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Rapid Aging
The second effect of the drug was to counter the regenerative speed of Muzan. He was so powerful that he could recover from the deadliest of strikes instantly and even if he were shredded into the littlest of pieces, he would regenerate within seconds.
The drug accelerated Muzan’s aging, causing him to age approximately 50 years per minute, which would drastically weaken his body over time. This made him very vulnerable, and after about 5 hours of the drug being consumed, Muzan started aging rapidly. He started to lose his strength and stamina and his attacks became much weaker.
Stopping Muzan From Escaping Battle
Tamayo knew that when Muzan reached the verge of defeat he would split himself into smaller parts to escape from the battlefield and regenerate himself after he reached a safe spot.
I don’t need to be stronger than you to kill you. I will just make you weaker. Just as you will do whatever it takes to stay alive, I, No, we will do whatever it takes to kill you – Tamayo to Muzan
So the third effect was to prevent Muzan from splitting himself up and escaping so that the corps could finish him once and for all.
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Breaking Muzan Down At The Cellular Level
The final and most lethal effect of the Anti-Kibutsuji drug was to kill Muzan by breaking down his body at a cellular level. This effect proved to be the ultimate key in defeating Muzan as his cells kept on dying over time, which also stopped his regenerating and healing abilities.
By the time the drug had completely taken over Muzan’s body, the demon king was falling apart. While he tried to keep himself alive by eating the members of the corps, none of it mattered as the drug had already done its job.
The Drug’s Role In Defeating Muzan
This drug was one of the key reasons why Demon Slayers were able to defeat Muzan for good. Without this, Muzan would have kept on fighting at his full potential and would have killed every single member of the corps in Demon Slayer.
If it wasn’t for Tamayo’s sacrifice to inject the drug into Muzan and Shinobu’s help to make it strong enough to defeat him, the demon king would have won easily.
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