Last year saw a newfound interest in Fallout bubble up, as the Amazon Prime live-action series offered a surprisingly well-done adaptation of the post-apocalyptic franchise. Fallout has been a gaming staple, and its reignited prominence in pop culture will hopefully pave the way for Fallout 5 to become reality sooner, rather than later.
As of now, there is no telling what awaits in Fallout 5, but Bethesda’s Todd Howard has at least confirmed in the past that the game is set to be on the company’s to-do list after The Elder Scrolls 6 arrives. Unfortunately, the latter is also taking a long time to reveal itself, but on the bright side, the Fallout TV series has offered its own unique, fresh chapter. One of the most fascinating characters introduced in the TV series is The Ghoul. This radiation-riddled cowboy serves as the story’s antihero, and one major plot point surrounding his Ghoul nature could be a strong addition to Fallout 5.

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The Ghoul’s Mysterious Medicine Could Pave the Way For a Similar Plot Point in Fallout 5
The Fallout TV Series Plays Around With Ghoul Lore
- The Ghoul takes an unspecified drug that keeps him from going feral.
Traditionally, Fallout doesn’t have a clear explanation for what makes some Ghouls feral while others remain relatively normal. A popular view held by a lot of fans is that the radiation eventually destroys every Ghoul’s brain over time, causing them all to go feral eventually. This could be the case, but the Fallout series taking the bold risk of offering viewers a clear explanation as to how The Ghoul stays in control of himself is worth exploring in the games, too.
Right now, the story of Fallout 5 is a huge mystery, but an anti-feral drug could present an interesting direction for the narrative to travel down. For example, one of the game’s companions or one of the protagonist’s loved ones could potentially be a Ghoul, tasking players with collecting vials of the drug in order to keep them from turning feral. It would likely be a major challenge, but it could definitely be one worth taking on if it leads to compelling plot points and extra lore. Including The Ghoul’s feral-proof drug in Fallout 5 would also add a sense of urgency to the game.
One prevailing theory as to what The Ghoul’s anti-feral drug could be is Radaway, which is a staple in the franchise.
One route that’s even more intriguing, though, is if the story’s protagonist was in fact the Ghoul who needs to collect the drug in order to stay coherent. The franchise’s multiplayer spin-off, Fallout 76, is about to introduce playable Ghouls for the first time, and Fallout 5 following in those footsteps isn’t outside the realm of possibility.
The Fallout TV Series Could Influence Fallout 5
- Fallout Season 2 is currently in the process of filming.
It’s not clear whether the Fallout show will inspire the story of Fallout 5 or not, but it’s definitely possible. The lore of Fallout is important, and the two eventually straying too far from one another could be disappointing. As the show gears up for its second season, Bethesda and the writers are bound to be working in tandem, especially since Todd Howard is credited as an executive producer on the project.
At the rate Bethesda is developing its games, it’s quite likely that the Fallout show may be in its third or fourth season by the time Fallout 5 is ready. If that’s the case, then the live-action series influencing future lore almost feels like a given. Only time will tell, but the Fallout show’s Ghoul lore retcon could be a welcome change included in future games.

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