Summary
- Discover powerful treasures like Epic Fetus, Death’s Touch, and Chaos Card in The Binding of Isaac: Rebirth.
- The randomized eight-level game offers tense challenges with 20 bosses to conquer and unique rewards to find.
- Challenge rewards like Gold Bomb and Get Out Of Jail Free Card provide valuable advantages during gameplay.
Bizarre, sometimes even surreal, treasures are there to be discovered when players embark upon the shooter roguelike epic that is The Binding of Isaac: Rebirth. Most definitely inspired by Rogue, this game is everything players could want in an unusual dungeon character crawler, and as a remake of the original, The Binding of Isaac: Rebirth is certainly one to stick in the memory of anyone who plays it.
![split image of Isaac, Cain, and Azazel in The Binding Of Isaac Rebirth](https://esportvoice.com/wp-content/uploads/2025/01/1735758277_The-Binding-Of-Isaac-Rebirth-Best-Characters.jpg)
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The randomized nature of the game, coupled with the harrowing plot where Isaac is being pursued by his mother as a sacrifice to her God, come together to create a tension-filled, eight-level game with a whopping twenty bosses to conquer. When players are planning their route through the dungeons, choosing which challenges and rewards to focus on becomes a priority. The following, ranked in order of usefulness and effectiveness, are the best challenge rewards in The Binding of Isaac: Rebirth, and where to find them.
6
Epic Fetus
Challenge Number 19
Challenge number 19 is The Family Man and this is the challenge players need to attempt and succeed in should they want to get their hands on the Epic Fetus. To make it even trickier, the special condition Blindfolded is activated during this challenge, whereby not only Isaac but Tainted Lilith and Lilith are also blindfolded.
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Epic Fetus is a tear modifier and, what’s more, is the highest priority tear modifier of them all; stronger than both Mom’s Knife and Brimstone. The effects of Epic Fetus are twofold. Isaac’s tears are replaced with efficient missiles and also, when launched, these missiles deal an impressive twenty times the normal damage.
5
Rune Of Jera
Challenge Number 2
The Binding of Isaac: Rebirth has a whole host of unlockable challenges, and Challenge number 2 is indeed an exciting one. Upon completion of the High Brow challenge, players will be rewarded with the Rune of Jera. Isaac begins this challenge with four starting items: Butt Bombs, Number One, E. Coli, and Flush!
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Upon succeeding against this challenge, the Rune of Jera is rewarded (ID. 5.300.33) and this particular rune is well worth having. Once owned, the Rune of Jera will allow clones of not only all the chests in the space, but also all pickups too, meaning players of every level will certainly find this rune more than a little useful.
4
Death’s Touch
Challenge Number 17
The powerful Death’s Touch is found in Waka Waka, which is Challenge number 17. In this challenge, the player begins with Strange Attractor and Anti-Gravity. The former essentially makes Isaac magnetic and enables him to pick up trinkets, not to mention monsters, automatically, and the latter allows Isaac’s tears to basically hover stationary in midair.
Upon completing Waka Waka, Death’s Touch is awarded, and it is definitely an asset to have in Isaac’s inventory. Not only does Death’s Touch multiply damage by one and a half, but it also enables piercing tears, replacing them with Death’s scythes and doubling the volume of tears produced.
3
Chaos Card
Challenge Number 9
The powerful Chaos Card can be found in challenge number 9, titled Demo Man. At the beginning of the challenge, Isaac has two starting items: Dr Fetus, which replaces tears with bombs, and the Remote Detonator, which will cause each of the bombs the player puts down to simultaneously explode.
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Once Demo Man is completed, players will be awarded the Chaos Card (ID. 5.300.42) and when it needs to be used, it is simply thrown directly in front of Isaac. When the Chaos Card is placed down, it will destroy absolutely anything, or anyone, in its path, making it an exceedingly advantageous reward.
2
Gold Bomb
Challenge Number 23
Upon successful completion of Challenge number 23 (Blue Bomber) in The Binding of Isaac: Rebirth, the player will be awarded the mighty and powerful Gold Bomb. Blue Bomber is certainly one of the game’s harder challenges, as not only is Isaac blindfolded, but he also begins the challenge with Mr. Mega, Kamikaze!, Pyromaniac, and Brother Bobby.
Although the Gold Bomb does not actually increase Isaac’s bomb or trinket inventory, it does allow him to use unlimited bombs anywhere in a room, no matter if his inventory bomb count is 100 or 0. Be aware, though, that Bomb Bums entirely overrides the Gold Bomb’s power, so avoid that combo at all costs.
1
Get Out Of Jail Free Card
Challenge Number 22
To obtain the valuable Get Out Of Jail Free Card, players must successfully complete Challenge number 22: SPEED! Even though SPEED! sounds relatively simple, with all enemies being in the same position as the player has seen before, every single enemy is sped up as if they were all holding the Broken Watch.
The Get Out Of Jail Free Card (ID. 5.300.47) is an incredibly special card, as it can open every single door in the current room Isaac is standing in, working in exactly the same way as Dad’s Key. This card even opens the door to the Mega Satan boss fight, allowing the player to take a significant shortcut through the dungeon.
![The Binding of Isaac Rebirth Tag Page Cover Art](https://esportvoice.com/wp-content/uploads/2025/02/The-Best-Challenge-Rewards-In-The-Binding-Of-Isaac-Rebirth.jpg)
Action
Adventure
Roguelike
Dungeon Crawler
- Released
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November 4, 2014
- ESRB
-
Mature 17+ // Mature 17+ Blood and Gore, Crude Humor, Violen
- Developer(s)
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Nicalis, Edmund McMillen
- Publisher(s)
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Nicalis
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