Most Iconic Best Friends Duos In Anime

Friendship is one of the most important aspects of shonen anime. Aimed at teens and young adults, the majority of these stories are filled with friendships that play a crucial role in defining both the characters and the outcome of a series. These bonds between characters help them to mature and better understand the world around them.

These friendships are formed between siblings, friends, classmates, and even rivals. The characters in such friendships push each other to their limits, and ultimately end up making each other better. With that in mind, here are some of the most iconic best friends in anime.

Updated on January 19, 2025 by Suzail Ahmad: The world of manga and anime is filled with many titles that teach their audience many valuable life lessons. They explore many important themes in depth, helping fans to understand them better. Friendship is one of the most common themes that has been put under the microscope.

Some of the highest-rated anime series use friendships as a means to make the characters more appealing. The bond between two characters can also be used to develop their personalities and to make them stronger. It’s quite apparent that friendship is an excellent plot device that can do wonders for the story, which is why so many authors have used it in their works. But not every anime duo works out. Only a few of them manage to etch their names in the fans’ minds.

28

Mob and Reigen

Mob and Reigen are a unique duo in more ways than one. They are not of the same age but have good chemistry. Reigen served as Mob’s mentor and helped him get through difficult moments. The two were constantly involved in dangerous missions, and they only succeeded because of their trust.

Mob and Reigen helped each grow mentally and emotionally. As the one with more experience, Reigen was often in charge of most missions. Initially, Reigen was manipulative but realized his folly towards the end. The duo had their ups and downs, but there is no denying that they’re among the most iconic best friends.

27

Senku and Taiju

Helped Each Other All The Time

Senku and Taiju have been friends since childhood. On the surface, Senku seems rude towards Taiju, but that’s the farthest thing from the truth. Despite calling him an oaf, Senku respects Taiju and knows he is superior in certain fields.

This is evident from Senku’s decision to rescue Taiju before anyone else. The two make a spectacular team. Senku is the brain behind difficult operations, while Taiju acts as the muscle. Together, they have overcome many challenges and will continue to do so till the very end.

26

Midoriya Izuku and Bakugo Katsuki

A Great Representation Of How Friendship Works

In the last decade, Midoriya and Bakugo have become two of the most well-known anime characters. Their friendship has been through many phases. Initially, they were close, but Midoriya’s inability to awaken his Quirk caused them to drift away.

Their friendship improved when the two boys joined U.A. Bakugo was impressed by Midoriya’s determination and his unwillingness to give up. With time, Bakugo and Midoriya even participated in several together.

25

Sailor Moon and Sailor Venus

One Of The Best Female Duos

Sailor Moon and Sailor Venus are two of the most iconic anime characters. Hailing from the Sailor Moon series, the two are not just similar in looks, but personality as well. Throughout the story, they have shown that they care about each other, going as far as being ready to lay down their lives to protect the other person.

Sailor Moon and Sailor Venus are also rather powerful. Individually, they can take down the biggest threats and complete all sorts of dangerous missions. When they team up, the effects are devastating, and even all the evil in the world dares not to challenge them.

24

Rayleigh and Roger

Together They Achieved The Unthinkable

Silvers Rayleigh and Gol D. Roger met each other many years prior to the current timeline. Roger approached Rayleigh and made him an offer that he couldn’t refuse. Ultimately, the two started the Roger Pirates. Roger became the captain, and Rayleigh was his right-hand man.

However, they did not let the labels stop them from being friends. They shared the occasional drink, and they talked about their lives. Rayleigh and Roger stayed friends until the latter turned himself in willingly to the Marines to be executed by them. The bond between them is so strong that Rayleigh still reminisces about his time with Roger.

23

Giorno And Bucciarati

One Laid Down His Life For The Other’s Cause

Giorno Giovanna and Bruno Bucciarati did not have the best of starts to their friendship. They were not too fond of each other, and they nearly killed each other when they met for the first time. However, the two eventually struck a connection and ended up becoming close friends.

In a way, Bruno and Giorno pushed each other to become better fighters. Despite being so close, they maintained their individuality, ensuring that things didn’t become too boring. Unfortunately, their friendship was cut short by Diavolo, who killed Bruno in battle. Even after his death, Bruno’s spirit remained with Giorno, which helped the latter to push on and beat Diavolo. It is safe to say that Giorno would have never accomplished his dream with Bruno.

22

Boruto and Kawaki

Despite The Differences, They Became Good Friends

Boruto and Kawaki aren’t exactly two peas in a pod, but they have a good dynamic in the first part of the manga. The two had very different upbringings. Boruto was coddled by his parents and treated well by the villagers, as he was the Hokage’s son. Kawaki, on the other hand, was physically abused by Jigen as the latter wanted him to become the perfect vessel for the rebirth of Isshiki Otsutsuki.

When Boruto and Kawaki met, they would always argue. Most of the time, it was due to a difference in opinions. With time, the two began to see each other’s perspective and got along well. They even fought enemies together and kept a watchful eye on each other’s backs.

21

Power and Denji

Different From Most Shonen Friendships

Despite having robust personalities, Power and Denji somehow managed to become good friends. Initially, they were always at each other’s throats, but with time, their relationship matured. Denji and Power share many similarities, which act as the basis for their friendship.

The two also have good coordination, which helps them fight against tough opponents without too many problems. The best thing about their friendship is that Denji and Power could be their real selves in front of one another. They didn’t have to pretend to be someone else, which is important for any good friendship. When Chainsaw Man returns with new seasons, fans will get the opportunity to watch the duo in action.

20

Tanjiro and Nezuko

Both Are Willing To Die For Each Other

Even though Tanjiro and Nezuko are siblings, it is hard to ignore the bond that the two share. After losing almost his entire family, Tanjiro was left with only Nezuko, who had been turned into a demon. The rules would dictate that Tanjiro would be killed by Nezuko, and the latter would meet her end at the hands of a Demon Slayer.

But the two were so attached to each other that they managed to overcome this hurdle. Tanjiro managed to stop Nezuko from consuming human flesh like ordinary demons. In order to protect her from the sun, he started carrying her in a large box on his back. They overcame many adversities by trusting themselves and risking their lives to keep each other safe. By the end of the series, the two become extremely powerful as well.

19

Jessie and James

Always Support Each Other

Jessie and James make up two-thirds of the iconic Team Rocket that fans grew up with and adore. Jessie and James constantly appear in episodes in hopes of nabbing Ash’s Pikachu and whatever valuable Pokemon may be available.

Unfortunately for them, they almost never manage to achieve their goals. In almost every episode, the iconic duo entertains the audience with their antics. They come up with new methods, which inevitably fail. Despite their inability to win, Jessie and James do not give up. Often, when one of them is feeling down, the other tries to cheer them up. This particular quality makes Jessie and James one of the better anime duos.

18

Einar and Thorfinn

Einar Helped Thorfinn Get Through A Torrid Time

When Einar met Thorfinn, he would have never thought that he would become friends with such a person. Einar and Thorfinn lived completely different lives before they ended up on the same farm. Thorfinn was a fearless warrior who mowed down anyone who stood in his path.

On the other hand, Einar was a farmer who loved his family. What makes their friendship beautiful is that they managed to cast their past aside. Einar helped Thorfinn deal with the troubles of his past. Eventually, they started working together and managed to secure their freedom from Ketil.

17

Kamina and Simon

Had An Unbreakable Bond

Kamina and Simon are two of the most well-known characters in the anime community. They knew each other for the majority of their lives. Kamina was an energetic individual who was not afraid to take risks. Simon was the total opposite; he was timid and often tried to stop Kamina from being reckless.

The two characters balanced each other nicely. Whenever Simon was feeling down, Kamina would give him words of encouragement. It wouldn’t be an overstatement to say that Kamina played a very crucial role in shaping Simon’s character. As the story progressed, Kamina’s influence began to rub off on Simon, and the latter managed to become a strong and capable individual.

16

Itadori and Todo

Both Were Talented Fighters

Itadori and Todo managed to strike up a friendship in the unlikeliest of situations. The two were supposed to be on opposing sides, but Todo saw potential in Itadori and labeled him as his best friend. Initially, Itadori was hesitant and didn’t want anything to do with Todo.

However, the senior Jujutsu sorcerer’s persistence paid off, and Itadori caved in. The two of them even joined hands to fight Hanami, one of the special-grade curses. Itadori and Todo’s friendship also provided fans with plenty of laughter and drama, giving the series a much-needed jovial mood.

15

King and Saitama

King Understands Saitama More Than Anyone

The duo of King and Saitama is quite different from the usual ones found in anime. For starters, one of them has very little power, while the other has copious amounts of it. King thrived off Saitama’s accomplishments, and he came to be known as the “Strongest Man Alive,” but it didn’t seem to bother the caped bald hero.

​​​The two bonded over their love for video games. Saitama was thoroughly impressed by King’s ability to beat him so easily at video games. This common interest helped the two become good friends. Since then, they have helped each other a lot. While Genos might be close to Saitama, the former doesn’t know a lot about him. Meanwhile, King understands Saitama, and he knows that he has his faults. By the time the series ends, the duo of Saitama and King will have definitely become even more iconic.

14

Johnny Joestar And Gyro Zeppeli

Worked Together To Achieve Their Goal

Johnny Joestar is the main protagonist of Steel Ball Run and Gyro Zeppeli is his main aide. The two met at the very beginning of the series and within a few chapters, the two became a duo. However, this was just the beginning of their friendship. The two of them inspired each other in ways that no one else could.

In particular, Johnny was deeply influenced by Gyro and his ideologies. Johnny became more confident in his abilities and finally understood the importance of friendship. Johnny adored his friend to the point that he was willing to trust Funny Valentine to bring him back to life.

13

Caiman And Nikaido

They Risk Their Lives To Protect Each Other

Caiman and Nikaido are two of the main characters from Dorohedoro. The two live in the Hole where Nikaido has her own shop. Caiman is a man of mystery as he does not know anything about his past. Due to an unfortunate incident, Caiman’s head was turned into that of a lizard.

The two have great fighting synergy as they have managed to take down numerous magicians. Together, Caiman and Nikaido killed many magic users to find more clues about the former’s condition. They care about each other in their own special ways.

12

Saichi Sugimoto And Asirpa

Experienced Many Adventures Together

The two of them are the main characters of Golden Kamuy. After finding out that there is a treasure hidden, Sugimoto decided to search for it, and he nearly died, but luckily Asirpa managed to rescue him from the clutches of death.

Once Asirpa came to know about the hidden gold, she decides to help Sugimoto find it. The two of them come across many dangers, but they always have each other’s backs. As the story progresses, the bond between the two only continues to improve.

11

Ei Sei And Xin

Were Close Despite The Difference In Their Status

Ei Sei was next in line to be crowned the King of Qin, but due to a clever plot from the enemies, Ei Sei had to wait for several years. He met Xin after his body double was murdered inside the castle.

The two of them did not have the best of starts to their friendship, but as time went on, both of them helped each other to grow and become better humans. Ei Sei’s trust in Xin reached new heights as the former entrusted him with the most important tasks. Eventually, Xin became Ei Sei’s most loyal and trusted companion.

10

Gon And Killua

Always Supportive Of One Another

Not many friendships compare to the companionship of Gon and Killua from Hunter x Hunter. The two met during the Hunter Exams and immediately became good friends. Since then, the two have reached the status of pro-hunters and faced my ordeals together.

The two complement each other perfectly. Gon likes to charge headfirst in any situation, while Killua carefully analyzes the situation before taking action. Their difference in approaches has saved their lives on countless occasions. Since the other characters are older than the two, they are the only ones who understand each other’s emotions.

9

Naruto And Sasuke

Understood Each Other’s Pain

Naruto is a shonen series that focuses heavily on the friendship between two people. There are other things to concentrate on within the plot, but the central point of the series is the friendship between Naruto and Sasuke, two very different yet similar individuals.

Sasuke left the village as he wanted to increase his power, and all the villagers gave up on him, everyone except Naruto. Naruto promised that he’d bring back Sasuke from the depths of darkness — and he did. Naruto taught Sasuke the importance of friendship and made him realize that there was more to life than he thought.