Games With Great Mutant Enemies

There are plenty of mutants to be found in the horror genre and beyond. At times, they have become a part of the natural landscape after a massive disaster. Other times, they are controlled by higher powers and sent your way as obstacles.

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The inclusion of mutants is a great way to squeeze some creative designs into a game, whether it means coming up with a completely original design or transforming a pre-existing creature into a monster. The origins of every mutant may be different, but some of them have stood the test of time as the best of the best.

10

Bioshock

Uncontrolled Scientific Progress

What happens when you let science run rampant in an isolated undersea utopia? You get a disaster where society collapses and humans will eat each other alive just to continue getting their fix of Adam.

Adam is everything in the city of Rapture. It gives you abilities beyond humanly possible, such as control over electricity or even fire. However, too much Adam can corrupt you, leading to a horrific transformation. You’ll become a Splicer and start hunting down other sources of Adam from the living or the dead.

9

Stalker 2: Heart Of Chornobyl

The World’s Most Dangerous Zone

Systems

Platform(s)

Xbox Series X and Series S
, Microsoft Windows

Released

2024-00-00

Developer(s)

GSC Game World

Publisher(s)

GSC Game World

ESRB

m

Stalker 2: Heart of Chornobyl takes place at the center of a radioactive area known as The Zone. Here, anything goes, making it the perfect place for those who want to stay out of the public eye or embrace the danger for money.

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The zone is filled with human enemies but also countless mutants that might end your life if you aren’t too careful. The good news is that all the worst mutants are trapped within the Zone. The bad news: you’re in there with them.

8

Fallout 76

It’s A Monster Mash

The Fallout series is based primarily on showcasing the aftermath and recovery of society after nuclear fallout. While mutants have always been around with Super Mutants being the creatures your mind immediately goes to, Fallout 76 tops every other game before it in terms of enemy designs.

There are mutant sloths, frogs, moths, and plenty of other creatures that you will only find in this game. There are also mutants roaming around the wasteland based on the cryptids from urban legends, which adds a whole different layer to the fun.

7

Resident Evil 4

The Most Devastating Virus Yet

The Resident Evil series is filled with biological horrors spawning from zombies, giant spiders, and creeping horrors that will gobble up any unsuspecting human. Resident Evil 4 swaps the zombie virus for a parasite that consumes its host, allowing them to mutate into horrific new forms.

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Las Plagas enables plenty of mutations into creatures such as the insect-like Novistador, the ferocious canines Los Colmillos, and the terrifying Gigante. The remake of Resident Evil 4 gives all these mutants glow ups, making them more detailed than ever before.

6

Zoochosis

Terror At The Zoo

Systems

Released

September 23, 2024

Developer

Clapperheads

Publisher

Clapperheads

ESRB

m

The zoo is a fun place to spend the day. Unless, of course, the animals start coming down with a mysterious disease that causes them to transform. As the newly hired zookeeper, you must find a way to save your animals while preventing the spread of the disease from consuming them all.

However, while a cure is possible, all the animals will become highly dangerous if allowed to turn. This will give them additional appendages, grotesque eyes, and fleshy aberrations that will make any fan of creepy creature designs happy.

5

Teenage Mutant Ninja Turtles: Mutants Unleashed

Fun Mutant Mayhem

Not every game with mutants needs to be horrific. In fact, Teenage Mutant Ninja Turtles always has cool mutants just begging for an action figure. Teenage Mutant Ninja Turtles: Mutants Unleashed is a 3D beat ’em up that follows up on the story seen in the film Mutant Mayhem.

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With the same stylized look, the Ninja Turtles must unravel the mystery behind their mutant brethren going wild. With more mutants arriving in New York after the events of the film, it’s up to the Ninja Turtles to keep the peace between humans and mutants.

4

Sons Of The Forest

Cannibals And Mutants

Systems

Released

February 23, 2023

Developer(s)

Endnight Games

ESRB

e

After crash landing on an isolated island, you must learn to survive the elements as well as your own bodily needs. Food, water, and shelter are only some of the things you need to worry about. You also have to deal with the mutated cannibals and monsters that will try to catch you by surprise.

The mutants in Sons of the Forest are unique since they can be found deep within underground caverns before they start poking their heads out into the sunlight. They are hostile towards both you and other enemies, which makes them incredibly dangerous.

3

The Outlast Trials

Mutants Are Part Of Your Trials

Mutants are a staple of the Outlast series. Whether they’re taking over a mansion facility or isolated villages, you will always need to run from these dangerous abominations. The Outlast Trials puts you in the shoes of a test subject who is taken by the Murkoff Corporation.

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Earn enough Release Tokens and you will be able to go free. This is easier said than done when every trial has dangerous mutants, making the tasks given to you difficult to accomplish. These can include mutants that disorient you through screams or that only appear once you’ve witnessed enough mind-breaking horror.

2

Left 4 Dead 2

The Special Infected Are Perfect

Systems

Released

November 17, 2009

ESRB

M for Mature: Blood and Gore, Intense Violence, Language

The Green Flu left those infected transformed into aggressive zombie-like creatures. However, it also created a group of special infected that mutated. These include the ensnaring Smokers, the deadly Hunters, and the acid spewing Spitters.

These are some of the best mutants, since they all complement each other with their abilities, with none of them feeling too broken or overpowered. This also makes them perfect for multiplayer mayhem. The introduction of the complete set of special infected in Left 4 Dead 2 made them some of the most memorable mutations in video game history.

1

Metro 2033 Redux

Life In The Tunnels Of Moscow

Metro 2033 may have fewer mutants than Metro Exodus, but the story revolves primarily around the mutants known as The Dark Ones. As Artryom tries to understand the world around him, he comes face to face with these creatures.

While they mean no harm towards humans, their psychic powers and radioactive bodies cause hallucinations. This makes them a target for humans who fear what they cannot comprehend. Their presence is not only integral to the plot, but makes the player question their own morals after the story is completed.

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