The First Descendant: Best Python Build

The Python is an Ultimate weapon in The First Descendant that stands out for its ability to debuff enemy defense and toxic resistance, making it useful against high-health targets, especially Colossi. However, its unique ability triggers only when hitting enemy Weak Points, so it’s most effective in focused battles rather than against swarms of Vulguses.

But if you want to harness the true power of this Ultimate weapon, you’ll need to put in a lot of attention to details, especially on the modules you equip on it. To help you maximize the DPS and get the most value, here’s a complete breakdown of how you should build the Python in The First Descendant.

What is Python in The First Descendant?

The Python is the Ultimate Weapon in The First Descendant, and is a su bmachine-gun with a unique ability called the Python Instinct. When you hit an enemy’s Weak Point, you trigger the Prey status, which reduces the target’s DEF and Toxic Resistance by 10 percent. This makes Python particularly effective against Colossi and enemies with high resistance. Python excels in single-target combat but struggles with crowd control due to its Weak Point dependency. Here are the base stats of the Python weapon to help you get a better idea of this weapon’s abilities:

Though the Python’s debuff benefits every Descendant, it’s especially effective for poison-focused characters like Freyna, who can capitalize on the lowered Toxic Resistance to further enhance her poison damage. It’s also a viable option for Ajax, given his tanky nature and high defense stats.

Best Early Game Python Build

In the early game, Python’s main role is to help you deal explosive damage to single target Vulguses, especially Weak Point targeting and exploiting the Prey debuff against bosses. Firearm ATK and Weak Point Damage are the essential modules for the early game build.

These modules focus on increasing the Weak Point damage to maximize Python’s potential, making it deadly against bosses and Colossi. You’ll have your weak point damage increased by almost 20 percent, which makes the damage numbers close to 2.5 times the base damage.

Best Late Game Python Build

In the late game, the Python’s potential skyrockets, especially against high-level Colossus enemies. To truly unlock its power, your build should focus on boosting its already high Weak Point damage and enhancing Toxic resistance debuffs, turning Python into a DPS machine that can shred through boss and elite encounters.

With the above build, the Python becomes a high-damage, precise weapon because of Fixed Shot and Mental Focus that is capable of dealing with even the toughest Colossi, especially when used by characters like Freyna, who can capitalize on the enhanced Toxic damage.

Best Python Build for Farming

When farming in The First Descendant, having a high fire rate and even higher DPS is essential. In such cases, Python can be a good choice for farming high-value resources, especially in regions dominated by electric-type enemies like Hagios or Kingston. With the above build, you can easily farm resources in most regions with ease, even on hard difficulty.

If you’re struggling in any of the regions on Hard difficulty, upgrading your module level is enough to clear them eventually.

Best Python Build for Void Intercept Battles

Void Intercept battles require high-impact weapons and Python is one of the few Ultimate Weapons that shine in this game mode. As it can inflict debuffs on the defense and Toxic resistance, it is particularly effective against solo bosses.

Your focus should be on maximizing damage by ensuring you consistently hit the Weak Points of the colossi. This build turns Python into an ideal weapon for shredding down Void Intercept bosses, especially the likes of Executioner, Devourer and the Hanged Man because of the additional type advantage.