The Best Binding of Isaac: Rebirth Final Bosses

Key Takeaways

• The Binding Of Isaac: Rebirth offers a unique and challenging gameplay experience with creative boss designs.
• Some bosses like Mom and It Lives provide beginner-friendly battles, while others like Hush and Delirium offer intense challenges.
• Players must adapt their strategies to defeat each boss in order to progress through the game successfully.

The Binding Of Isaac: Rebirth is an iconic, randomized rogue-like shooter developed by Nicalis, Inc. and Edmund McMillen – the talented designer behind Super Meat Boy. In the game, players take control of Isaac, a young boy fleeing the deadly wrath of his mother in the ever-deepening depths of the earth.

Boasting a sprawling array of enemies to fight, game-changing items to collect, and random generation that ensures no two games are the same, The Binding Of Isaac: Rebirth is a timeless indie classic. One of its strongest suits is its bosses. Creative in their designs and attack patterns, each boss provides a unique challenge for players to overcome, whether in the frenzied attacks of Mother, the bullet hell of Hush, or the battle of attrition that is The Beast. Players must tailor their playstyles and builds to accommodate each boss. Failure to do so will be punished with death.

This article includes content from all The Binding Of Isaac: Rebirth DLCs.

10 It Lives

Simple To Learn, Simple To Master

• HP: 950
• Found In: Womb, Utero, & Scarred Womb
• DLC: None – Base Game Content
• Visual Design Rating: B-

It Lives, the second boss of The Binding of Isaac: Rebirth, is a beginner-friendly boss with low HP and easy-to-learn attack patterns. It also serves as a crucial benchmark against which players can test the strength of their builds. As one of the easiest bosses in the game, players struggling to defeat it will likely meet a grisly fate on subsequent floors.

It Lives is an exciting battle for new players. For Rebirth veterans, however, this fight can be lackluster, with much of its difficulty coming from a lack of items or poor item RNG rather than intentional design.

9 Satan

Thrilling And Varied, But Easy To Break

• HP: 1,200
• Found In: Sheol
• DLC: None – Base Game Content
• Visual Design Rating: C+

With three different stages and attack styles, Satan is a thrilling end to the Sheol floor. Kamikaze leeches and brimstone lasers keep players on their toes, frantically dodging lasers, bombs, and bullets. Any lapse in concentration will be punished with explosions, evisceration, and the loss of valuable hearts.

A blessing for some and a disappointment for others, Satan, with its low HP and easy-to-learn attacks, can be brute-forced. This, alongside the ease with which The Fallen and kamikaze leeches can be dispatched by most builds, can leave Satan feeling disappointingly easy to defeat at times.

8 Mom

A Fantastic Intro To Final Boss Fights

• HP: 645
• Found In: Depths, Necropolis, Dank Depths, Mausoleum, & Gehenna
• DLC: None – Base Game Content
• Visual Design Rating: B-

The first boss of Rebirth, Mom (commonly called Mom’s Foot) demands a delicate balance from players. They must simultaneously fight her and her minions, dodge both of their attacks, and maintain crowd control, adding a layer of intensity to the fight. Her stomping foot and door attacks also add an element of unpredictability. Mom sets the stage for Rebirth boss fights, with each subsequent boss offering a unique twist to this formula.

Fighting Mom can become repetitive over time, as it is one of two mandatory game bosses. There’s only so much excitement a boss can generate when fought so often.

7 Mother

Bullet Hell Chaos

• HP: 4,222
• Found In: Corpse
• DLC: Repentance
• Visual Design Rating: B+

Standing as one of the most difficult bosses to encounter, Mother is a challenge players dare to face. Once in the fight, players are met with a frantic bullet hell that has even veterans sweating with fear. With the right strategies and quick thinking, however, even the daunting challenge that is Mother can be overcome. The cost of failure is enormous, as collecting the knife pieces is elaborate and dangerous. This boss is not for the faint-hearted, but for those who enjoy a strategic challenge, she is a worthy opponent.

Mother would rank higher on this list if she had better replayability. Several tricks make some of her attacks easy to avoid, and time-slowing items such as the Stop Watch and I’m Drowsy… pills nullify her threat.

6 Ultra Greedier

A Golden End To Greedier Mode

• HP: 2,500
• Found In: Ultra Greed (Greedier Mode Only)
• DLC: Afterbirth+
• Visual Design Rating: A

Ultra Greedier is the engaging second phase of Ultra Greed, which pairs the fast-paced action and chaotic crowd control of Ultra Greed with a frantic second-stage fight for survival. In his second stage, players must avoid being crushed, trampled, and shot by a highly aggressive Ultra Greedier, all the while avoiding brimstone lasers from golden boss doors.

This second stage provides an extra layer of challenge to players looking to complete Greedier Mode, pushing players that bit further to achieve victory. Ultra Greedier is a fitting end to the hardest difficulty of Greed Mode.

5 Dogma

A Test Of Worthiness

• HP: 2,400
• Found In: Home
• DLC: Repentance
• Visual Design Rating: A

As the precursor to The Beast fight, Dogma provides a fierce and fast-paced battle. Mistakes are harshly penalized, and any hesitation can lead to demise. Dogma’s intense, bullet hell style attacks leave little room for error, serving as a test of strength and skill. If a player dies to Dogma, it’s a clear sign that they wouldn’t have survived The Beast.

For those powerful enough to best Dogma, this fight is an intense struggle for resource management. Every heart, bomb, and active item players exhaust here will be one less they have to fight The Beast with, cranking up the tension of this battle even further.

4 Mega Satan

A Nail Biting Battle

• HP: 5,000
• Found In: Chest & Dark Room
• DLC: None – Base Game Content
• Visual Design Rating: B+

Boasting two phases, various attack patterns, and numerous mini-boss spawns, Mega Satan is anything but a boring boss to fight. His frequent alternation between attacking the player and spawning enemies ensures something new is always happening, keeping players constantly on their toes. The mini-boss waves further heighten the pressure, forcing players to fight multiple powerful enemies in a small space. Resource management is vital for surviving this extended fight.

Some items like Mom’s Contact and Ocular Rift can make this fight a breeze. This is a positive for some players, enabling fast progression through the run. For others, though, being able to brute force Mega Satan strips the battle of its stakes.

3 Delirium

Teleportation Mania

• HP: 10,000
• Found In: The Void
• DLC: Afterbirth+
• Visual Design Rating: B-

Delirium offers players a frenzied, high-octane battle. Its constant transformations, changing attack patterns, and teleportation gives unpredictability to this fight, forcing players to constantly adapt their strategies to counter whatever form it has taken. The final boss of most runs (if it spawns), this battle sees players fighting at their full force. Every bomb, laser, and familiar collected during the run is at the player’s, making for explosively chaotic final battles.

Delirium’s single drawback is its tendency to spawn on and subsequently damage players. In a battle where every heart counts, this loss can feel more than a little unfair, especially for low-hearted characters such as The Lost or Tainted Lost.

2 Hush

A Trial Of Composure Like No Other

• HP: 6,666
• Found In: ???
• DLC: Afterbirth
• Visual Design Rating: C

With its intense bullet hell action and resistance to brute force, Hush stands out among the Rebirth bosses. Unlike with other bosses, strength alone will not win players the fight, and even the most godlike of builds can easily fall victim to Hush’s barrage of continuum bullets. Balancing dealing damage with dodging is the key to beating this boss. This requires a keen strategy, swift identification of attack patterns, and expert skills to pull off.

To face off against Hush, players must defeat It Lives in under 30 minutes, necessitating that most players rush through floors, leaving potentially game-changing items behind and making Hush all the more difficult to beat. Those who defeat Hush are rewarded with the chance to face Delirium.

1 The Beast

A Hellishly Beautiful Conclusion

• Base HP: 10,000
• Found In: Home
• DLC: Repentance
• Visual Design Rating: A+

Standing as the final boss in The Binding Of Isaac: Rebirth, The Beast is an excellent send-off to this beloved series. She is a thrilling joy to fight in this epic battle of attrition that stretches players’ skills and resources to their limits. While long, every moment of this battle is action-packed, with players needing to fight through 4 Ultra Harbingers before even getting to The Beast, all the while exhausting their resources.

Every moment sees players pushed closer to the brink of death. Nothing short of power and perfection will bring victory. For players who do manage to beat her, the sense of accomplishment and pride is unrivaled.